Knowledge Base

Fructose intolerance

What is fructose intolerance?
Hereditary fructose intolerance is an inborn metabolic disorder based on an enzyme deficiency which is necessary for proper metabolism of ingested fructose. It is an autosomal recessive mutation in the gene ALDOB (aldolase B). In case of enzyme deficiency, fructose can not be metabolised completely leading to fructose-1-phosphate (an intermediate) accumulation. High amounts of accumulated fructose-1-phosphate then cause liver cell death.

What are symptoms of fructose intolerance?
Hypoglycemia, vomiting, abdominal pain and irritability

How to manage a fructose intolerance
Fructose intolerance can be treated with a special fructose-free diet, as well as by avoiding fructose precursors. Food labels must be read carefully and foods containing following should be avoided:

• Fructose
• High-fructose corn syrup
• Honey
• Agave syrup
• Invert sugar
• Maple-flavored syrup
• Molasses
• Palm or coconut sugar
• Sorghum